Setmelanotide

Also known as: Imcivree, RM-493

MetabolicFDA APPROVED

Clinical Status

FDA Approved — genetic obesity (POMC, PCSK1, LEPR deficiency).

Mechanism of Action

A selective MC4 receptor agonist that restores melanocortin signaling in patients with genetic disruptions of the leptin-melanocortin pathway. Reduces hunger and increases energy expenditure.

Dosing Defaults

Dose

1-3 mg daily

Frequency

1x daily

Administration

Subcutaneous injection

Timing

Morning

Food

with or without

Duration

Long-term / chronic use

Dose range: 0.5-3 mg daily

Morning dosing supports appetite suppression throughout the day.

Side Effects

•Injection site reactions
•Skin hyperpigmentation
•Spontaneous penile erection
•Depression
•Nausea
•Diarrhea

Contraindications & Warnings

•Not medical advice
•FDA approved only for specific genetic mutations
•Depression and suicidal ideation monitoring required

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This information is for educational purposes only and is not medical advice. Dosing data is based on research literature and community reports. Always consult a qualified healthcare provider before using any peptide.