AICAR

Also known as: Acadesine, Aminoimidazole carboxamide ribonucleotide

MetabolicPHASE 2

Clinical Status

Investigational — clinical trials for cardiac ischemia. WADA prohibited.

Mechanism of Action

Directly activates AMP-activated protein kinase (AMPK) without requiring prior phosphorylation. Mimics exercise signaling: increases glucose uptake, fatty acid oxidation, and mitochondrial biogenesis in skeletal muscle.

Dosing Defaults

Dose

50-150 mg

Frequency

1x daily

Administration

Subcutaneous injection

Timing

Pre-exercise or morning

Food

fasted

Duration

4-8 weeks

Dose range: 50-500 mg per dose

Pre-exercise timing maximizes AMPK activation synergy with physical activity.

Side Effects

•Lactic acidosis risk
•Hypoglycemia
•Cardiac effects (bradycardia)
•Nausea
•Diarrhea

Contraindications & Warnings

⚠Cardiac arrhythmias
⚠Hypoglycemia-prone conditions

•Not medical advice
•WADA prohibited substance

Compare

Compare AICAR with another peptide side-by-side.

Calculate Dose

Use the reconstitution calculator to prepare your AICAR dose.

Open Calculator

Related Metabolic Peptides

5-Amino-1MQ

PRECLINICAL

Metabolic

NNMT inhibitor that boosts NAD+ for fat metabolism. Does not affect appetite.

Adipotide

PRECLINICAL

Metabolic

Vascular-targeting peptide that destroys blood supply to fat tissue.

Tesofensine

PHASE 3

Metabolic

Triple monoamine reuptake inhibitor for appetite suppression and thermogenesis.

Setmelanotide

FDA APPROVED

Metabolic

MC4R agonist for rare genetic obesity. FDA-approved for specific mutations.

This information is for educational purposes only and is not medical advice. Dosing data is based on research literature and community reports. Always consult a qualified healthcare provider before using any peptide.