PT-141

Also known as: Bremelanotide, Vyleesi

HormonalFDA APPROVED

Clinical Status

FDA Approved — HSDD in premenopausal women.

Mechanism of Action

Activates melanocortin receptors, particularly MC4R in the CNS. Unlike PDE5 inhibitors, works through brain sexual arousal pathways, affecting desire centrally.

Dosing Defaults

Dose

1.75 mg

Frequency

As needed

Administration

Subcutaneous injection

Timing

1-2 hours before sexual activity

Food

with or without

Duration

As needed

Dose range: 0.5-2 mg per dose

Onset of effects is 45-60 minutes after injection.

Side Effects

•Nausea (40%)
•Facial flushing (20%)
•Injection site reactions
•Headache
•Transient blood pressure increase
•Skin hyperpigmentation with frequent use

Contraindications & Warnings

⚠Uncontrolled hypertension

•Not medical advice

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This information is for educational purposes only and is not medical advice. Dosing data is based on research literature and community reports. Always consult a qualified healthcare provider before using any peptide.