Semaglutide

Also known as: Ozempic, Wegovy, Rybelsus

Weight LossFDA APPROVED

Clinical Status

FDA Approved — T2D, weight loss, CV risk, kidney protection.

Mechanism of Action

Mimics the GLP-1 hormone, slowing gastric emptying, increasing insulin secretion, reducing glucagon release, and acting on brain appetite centers to reduce hunger and increase satiety.

Dosing Defaults

Dose

1-2.4 mg weekly

Frequency

Once weekly

Administration

Subcutaneous injection weekly, or oral

Timing

Morning, same day each week

Food

with or without

Duration

Long-term / chronic use

Dose range: 0.25-2.4 mg weekly

Weekly injection — consistency of day matters more than time of day.

Side Effects

•Nausea
•Vomiting
•Diarrhea
•Constipation
•Abdominal pain
•Headache
•Fatigue
•Gallbladder problems
•Pancreatitis

Contraindications & Warnings

⚠Personal/family history of medullary thyroid carcinoma
⚠MEN 2 syndrome

•Not medical advice
•BOXED WARNING: Thyroid C-cell tumors

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This information is for educational purposes only and is not medical advice. Dosing data is based on research literature and community reports. Always consult a qualified healthcare provider before using any peptide.