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MOTS-c

Also known as: Mitochondrial ORF of the 12S rRNA type-c

Anti-Aging & LongevityPRECLINICAL

Clinical Status

Preclinical — early human studies beginning.

Mechanism of Action

Encoded by mitochondrial DNA and acts as a mitokine. Activates AMPK, improves glucose uptake, enhances fatty acid oxidation, and has systemic metabolic regulatory effects.

Dosing Defaults

Dose

5-10 mg weekly

Frequency

1-3x weekly

Administration

Subcutaneous injection

Timing

Morning or pre-workout

Food

fasted

Duration

Variable by protocol

Dose range: 5-15 mg per week

Pre-workout timing enhances metabolic benefits.

Side Effects

  • •Injection site reactions
  • •Palpitations
  • •Nausea and bloating
  • •Fatigue
  • •May trigger histamine release

Contraindications & Warnings

  • •Not medical advice

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This information is for educational purposes only and is not medical advice. Dosing data is based on research literature and community reports. Always consult a qualified healthcare provider before using any peptide.