MK-677

Also known as: Ibutamoren, Nutrobal

Growth HormonePHASE 2

Clinical Status

Investigational — Phase II trials halted. FDA enforcement ongoing.

Mechanism of Action

Binds to ghrelin receptors in the brain, stimulating sustained GH release and increasing IGF-1 levels. Orally bioavailable with a long half-life providing 24-hour GH elevation.

Dosing Defaults

Dose

10-25 mg

Frequency

1x daily

Administration

Oral

Timing

Before bed

Food

with or without

Duration

8-12 weeks

Dose range: 10-50 mg daily

Evening dosing aligns with natural GH release during sleep.

Side Effects

•Increased appetite and hunger
•Weight gain
•Water retention
•Insulin resistance
•Elevated blood glucose
•Anxiety
•Muscle or joint pain

Contraindications & Warnings

⚠Diabetes or insulin resistance
⚠Heart failure risk

•Not medical advice
•Phase II trial halted for safety

Compare

Compare MK-677 with another peptide side-by-side.

Calculate Dose

Use the reconstitution calculator to prepare your MK-677 dose.

Open Calculator

Related Growth Hormone Peptides

Ipamorelin

PHASE 2

Growth Hormone

Selective GH secretagogue. Considered one of the safest GHRPs.

CJC-1295

PHASE 2

Growth Hormone

Synthetic GHRH analog that stimulates GH release from the pituitary.

CJC-1295 DAC

PHASE 2

Growth Hormone

Long-acting version of CJC-1295 with extended half-life via albumin binding.

Tesamorelin

FDA APPROVED

Growth Hormone

FDA-approved GHRH analog for visceral fat reduction in HIV lipodystrophy.

This information is for educational purposes only and is not medical advice. Dosing data is based on research literature and community reports. Always consult a qualified healthcare provider before using any peptide.