DAMGO

Also known as: [D-Ala2, N-MePhe4, Gly-ol]-enkephalin

Pain & AnalgesicPRECLINICAL

Clinical Status

Research tool compound — not developed for clinical use.

Mechanism of Action

A highly selective mu-opioid receptor agonist peptide used as a research tool. Produces potent analgesia through mu-receptor activation in the CNS, mimicking endogenous enkephalin signaling with greater selectivity.

Dosing Defaults

Dose

Research use only

Frequency

Research protocols

Administration

Intrathecal or intracerebroventricular (research)

Timing

Per research protocol

Food

with or without

Duration

Research use only

Dose range: Research dosing protocols only

Used in controlled research settings only.

Side Effects

•Respiratory depression
•Sedation
•Dependence/tolerance
•Constipation
•Nausea
•Pruritus

Contraindications & Warnings

⚠Respiratory insufficiency
⚠Concurrent CNS depressants

•Not medical advice
•Research compound only — NOT for human therapeutic use
•Opioid receptor agonist — abuse potential

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This information is for educational purposes only and is not medical advice. Dosing data is based on research literature and community reports. Always consult a qualified healthcare provider before using any peptide.